TY - JOUR AU - Guralp, Onur AU - Tuten, Nevin AU - Oncul, Mahmut AU - Acikgoz, Serdar A AU - Ekmekci, Hakan AU - Tuten, Abdullah PY - 2020/12/25 Y2 - 2024/03/29 TI - Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia JF - Gynecology Obstetrics & Reproductive Medicine JA - Gynecol Obstet Reprod Med VL - 26 IS - 3 SE - Obstetrics; Maternal Fetal Medicine and Perinatology DO - 10.21613/GORM.2018.918 UR - https://www.gorm.com.tr/index.php/GORM/article/view/918 SP - 166-172 AB - <p><strong>Objective:</strong> To evaluate the serum neutrophil gelatinase-associated lipocalin levels in pregnant women with and without preeclampsia, early-onset preeclampsia and late-onset preeclampsia, preeclampsia with and without severe features, and investigate the correlation with the neonatal outcomes.</p><p><strong>Study Design:</strong> A total of 79 pregnant women, 27 with uncomplicated pregnancies, 30 with early-onset preeclampsia, and 22 with late-onset preeclampsia were evaluated in a cross-sectional study. Neutrophil gelatinase-associated lipocalin was measured with a colorimetric Sandwich-ELISA method. Age; body mass index; systolic and diastolic blood pressure; umbilical-artery Doppler results; serum urea, bilirubin, uric acid, AST, ALT; 24-hour protein test; birth-weight; and Apgar-scores were recorded.<br /><strong></strong></p><p><strong>Results:</strong> Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia (p&lt;0.001); in women with early-onset preeclampsia compared to those with late-onset preeclampsia (p&lt;0.001); and in women with late-onset preeclampsia compared to those without preeclampsia (p=0.028). Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features (p=0.076). The correlation analysis showed that neutrophil gelatinase-associated lipocalin was not affected by age or body mass index. Neutrophil gelatinase-associated lipocalin had a positive correlation with systolic and diastolic blood pressure and the umbilical-artery PI and RI. Serum neutrophil gelatinase-associated lipocalin had a positive correlation with serum urea (r=0.416, p=0.031) however had no significant correlation with birth-weight, Apgar-scores, uric acid and amount of proteinuria in women with preeclampsia.<br /><strong></strong></p><p><strong>Conclusion:</strong> Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia; in women with early-onset preeclampsia compared to those with late-onset preeclampsia, and in women with late-onset preeclampsia compared to women without preeclampsia. Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features.</p> ER -