TY - JOUR AU - Yıldırım Küpesiz, Gökben AU - Peştereli, Hadice Elif AU - Erdoğan, Gülgün AU - Şimşek, Mehmet AU - Karaveli, Fatma Şeyda PY - 2006/08/17 Y2 - 2024/03/29 TI - Expression of Epidermal Growth Factor Receptor (Egfr) in Mole Hydatidiforms, Exaggarated Placental Sites and Normal Placentas and Ki 67 in Mole Hydatidiforms and Normal Placentas JF - Gynecology Obstetrics & Reproductive Medicine JA - Gynecol Obstet Reprod Med VL - 12 IS - 2 SE - Obstetrics; Maternal Fetal Medicine and Perinatology DO - UR - https://www.gorm.com.tr/index.php/GORM/article/view/573 SP - 82-84 AB - <p>OBJECTIVE: The aim of this study is to find out differences between expression of EGFR (epidermal growth f actor receptor) and Ki 67 labeling index (LI) in complete, incomplete mole hydatidiforms, exaggareted placental sites and normal placentas.<br />STUDY DESIGN: Eighteen incomplete, 7 complete hy datidif orm moles, 19 exaggareted placental sites and 10 placentas (control group) were studied immunohistochemically for EGFR (epidermal growth f actor receptor)and Ki 67.<br />RESULTS: Ki 67 LI of villous cytotrophoblasts differed significantly between complete and incomplete hydatidiform moles (p &lt; 0.01). Ki67 LIs of hydatidiform moles were significantly higher than control group (p &lt; 0.001). EGFR (epidermal growth factor receptor)staining of villous cytotrophoblasts differed signif icantly between complete, incomplete hydatidiform moles and control group (p &lt; 0.001). EGFR (epidermal growth f actor receptor) expression of syncytiotrophoblast differed signif icantly between complete, incomplete hydatidiform moles and control group (p &lt; 0.001).<br />CONCLUSION: Expression of EGFR (epidermal growth f actor receptor)in syncytiotrophoblast and cy totrophoblasts is important in the pathogenesis of complete and incomplete hydatidiform moles. Ki67 LI can be a useful marker in differentiating complete and incomplete moles.</p> ER -