@article{Ata_Kulhan_Kulhan_Turkler_Bilgi_Celik_2022, place={Ankara, TR}, title={Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery}, volume={28}, url={https://www.gorm.com.tr/index.php/GORM/article/view/1193}, DOI={10.21613/GORM.2021.1193}, abstractNote={<p><strong>OBJECTIVE:</strong> Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations. Rifamycin is a broad-spectrum semisynthetic antibiotic that is bactericidal against gram (+) and gram (˗) microorganisms. To the best of our knowledge, there are no studies on the use of rifamycin in antibiotic prophylaxis. In this study, we aimed to analyze whether there is a difference between the use of only cefazolin and only rifamycin in terms of surgical site infections.</p> <p><strong>STUDY DESIGN:</strong> One hundred patients were included in this case-control study during the last quarter period of 2017. These patients (n=100) were divided into two groups according to their antibiotic use; 50 patients who received only 1 g cefazolin constituted Group 1, 50 patients who received only 250 mg topical rifamycin over the incision line based on surgeon’s preference constituted Group 2.</p> <p><strong>RESULTS:</strong> The use of prophylactic topical rifamycin reduced the incidence of wound infection. compared with cefazolin. Surgical site infection was detected in 5 (10%) of the patients who received cefazolin, whereas surgical site infection was not observed in patients who received rifamycin (p=0.022).</p> <p><strong>CONCLUSIONS:</strong> The use of topical rifamycin is effective but does not imply that systemic antibiotics should replace prophylaxis. The use of rifamycin would aid in systemic antibiotic prophylaxis.</p>}, number={1}, journal={Gynecology Obstetrics & Reproductive Medicine}, author={Ata, Nahit and Kulhan, Mehmet and Kulhan, Nur Gozde and Turkler, Can and Bilgi, Ahmet and Celik, Cetin}, year={2022}, month={Mar.}, pages={76–81} }