The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy

Authors

DOI:

https://doi.org/10.21613/GORM.2019.942

Keywords:

First trimester, Prognosis, Serum progesterone

Abstract

OBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining first-trimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis in short time period. This study evaluated the predictive value of a single serum progesterone measurement in first-trimester pregnancy loss.

STUDY DESIGN: A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital. The study compared 106 patients with threatened abortion (vaginal bleeding or spotting) before 13 weeks of gestation with 110 healthy control pregnancies. Samples of serum progesterone were obtained on the day each patient was admitted to the hospital. A Beckman-Coulter macro-Enzyme-linked immunoassay (ELISA) system was used to measure serum levels of progesterone (Beckman-Coulter, Ireland).

RESULTS: Progesterone levels were measured when the patients first visited the hospital and they were followed until the end of the first trimester. Progesterone levels differed significantly (p=0.013) between the two groups. The spontaneous abortion rate was significantly (p=0.044) higher in the case group. Progesterone levels differed significantly (p=0.001) between ongoing pregnancy and spontaneous abortion groups. Using a cut-off level of 10.7 ng/mL, the sensitivity, specificity, and positive and negative predictive values were 92.1%, 44%, 92.6%, and 42.3%, respectively, for viable pregnancies.

CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.

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Author Biographies

Mehmet Nafi Sakar, Memorial Diyarbakir Hospital

Department of Obstetrics and Gynecology

Deniz Balsak, School of Medicine, Halic University

Department of Obstetrics and Gynecology

Sureyya Demir, School of Medicine, Dokuz Eylul University

Department of Obstetrics and Gynecology

Mehmet Sukru Budak, Diyarbakir Gazi Yasargil Education and Research Hospital, Health Sciences University

Department of Obstetrics and Gynecology

Ali Emre Tahaoglu, Diyarbakir Gazi Yasargil Education and Research Hospital, Health Sciences University

Department of Obstetrics and Gynecology

Sinan Emre Gungor, Suleymaniye Education and Research Hospital, Health Sciences University

Department of Obstetrics and Gynecology

Emrullah Akay, Suleymaniye Education and Research Hospital, Health Sciences University

Department of Obstetrics and Gynecology

Bulent Demir, School of Medicine, Onsekiz Mart University

Department of Obstetrics and Gynecology

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Published

2020-03-20

How to Cite

1.
Sakar MN, Balsak D, Demir S, Budak MS, Tahaoglu AE, Gungor SE, Akay E, Demir B. The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy. Gynecol Obstet Reprod Med [Internet]. 2020Mar.20 [cited 2021Mar.2];26(1):1-5. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/942

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Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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