Beta-Human Chorionic Gonadotropin and Uterine Artery Doppler Measurements for the Prediction of Success of Single Dose Methotrexate Treatment in Tubal Ectopic Pregnancies

Authors

  • Kılıç Çiğdem Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara
  • Mehmet Metin Altay Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara
  • Tuğba Kınay Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara
  • Metin Kaplan Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara
  • Serap Fırtına Tuncer Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara
  • Enis Özkaya Zeynep Kamil Women’s and Children Health Training and Research Hospital, Ankara
  • Ahmet Okyar Erol Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara
  • Orhan Gelişen Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara

DOI:

https://doi.org/10.21613/GORM.2016.90

Keywords:

β-Human chorionic gonadotropin, Ectopic pregnancy, Methotrexate, Single dose, Uterine artery Doppler

Abstract

Objectives: To evaluate the impact of the uterine artery Doppler values and the change of β-Human chorionic gonadotropin (β-HCG) levels from day 0 to day 4 for prediction of the success of single dose methotrexate treatment in tubal pregnancy cases.
Study Design: 50 patients with tubal pregnancy were included the prospective study. The location and size of ectopic pregnancy, bilateral uterine artery pulsed color doppler imaging was examined by ultrasonography and serum β-HCG levels were measured on day 0, 4, 7 of treatment. Success was defined as decrease of β-HCG level <10 mIU/mL with single dose methotrexate treatment. Multiple dose methotrexate treatment and surgical treatment were considered as treatment failure.
Results: 32 patients (64%) treated with single dose methotrexate, 14 patients (28%) treated with multiple dose methotrexate, and 4 patients (8%) treated with surgery. In the group with β-HCG level decrease > 15.04% on day 4, single-dose methotrexate therapy were 3.82 times more successful than the group without > 15.04% β-HCG decrease. However, no significant alteration of uterine artery Doppler measurements was determined on the same days.
Conclusion: Reduction rate in the β-HCG level on day 4 of treatment can be used in determination the success of single-dose methotrexate therapy.

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Published

2016-04-29

How to Cite

1.
Çiğdem K, Altay MM, Kınay T, Kaplan M, Tuncer SF, Özkaya E, Erol AO, Gelişen O. Beta-Human Chorionic Gonadotropin and Uterine Artery Doppler Measurements for the Prediction of Success of Single Dose Methotrexate Treatment in Tubal Ectopic Pregnancies. Gynecol Obstet Reprod Med [Internet]. 2016Apr.29 [cited 2021Jun.23];22(1):22-6. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/90

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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