Serum Albumin Level Adjusted Progesterone Level on the Trigger Day is Not a Significant Predictor of Clinical Pregnancy

Authors

  • Cigdem Yayla Abide Zeynep Kamil Women and Children’s Health Training and Research Hospital
  • Enis Ozkaya Zeynep Kamil Women and Children’s Health Training and Research Hospital
  • Semra Kayatas Eser Zeynep Kamil Women and Children’s Health Training and Research Hospital
  • Belgin Devranoğlu Zeynep Kamil Women and Children’s Health Training and Research Hospital
  • Bulent Emre Bilgic Zeynep Kamil Women and Children’s Health Training and Research Hospital
  • Tayfun Kutlu Zeynep Kamil Women and Children’s Health Training and Research Hospital

DOI:

https://doi.org/10.21613/GORM.2017.771

Keywords:

Albumin, Implantation success, Clinical pregnancy, Progesterone, Trigger day

Abstract

Objective: We aimed to assess the effect of serum albumin level adjusted progesterone levels on the trigger day on clinical pregnancy rate in ICSI cycles.

Study Design: A total of 100 women undergoing ICSI cycles due to poor ovarian reserve or tubal factor infertility were included in this study. Serum progesterone and albumin levels on the trigger day were utilized to predict clinical pregnancy among normal and poor responders.

Results: There were significant differences between groups with and without successful clinical pregnancy in terms of serum albumin (4.6 vs. 4.3 g/dl), progesterone levels (0.5 ng/mL vs. 0.7 ng/mL) on the trigger day and endometrial thickness (11.5 mm vs. 9.3 mm) (p<0.05, p<0.05 and p<0.05, respectively). In ROC analyses, progesterone level on the trigger day was found to be a significant predictor of clinical pregnancy (AUC=0.652, p=0.015). An optimal cut-off value of 0.55 ng/mL was obtained with 65% sensitivity and 57% specificity. Albumin level adjusted progesterone concentrations on the trigger day were 0.67 ng/mL versus 0.64 ng/mL, but this difference was not statistically significant (p>0.05). 

Conclusion: Albumin adjusted progesterone concentrations may be utilized to determine cases for a freeze-all policy.

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Author Biographies

Cigdem Yayla Abide, Zeynep Kamil Women and Children’s Health Training and Research Hospital

Department of Reproductive Medicine and Infertlity

Enis Ozkaya, Zeynep Kamil Women and Children’s Health Training and Research Hospital

Department of Reproductive Medicine and Infertlity

Semra Kayatas Eser, Zeynep Kamil Women and Children’s Health Training and Research Hospital

Department of Reproductive Medicine and Infertlity

Belgin Devranoğlu, Zeynep Kamil Women and Children’s Health Training and Research Hospital

Department of Reproductive Medicine and Infertlity

Bulent Emre Bilgic, Zeynep Kamil Women and Children’s Health Training and Research Hospital

Department of Reproductive Medicine and Infertlity

Tayfun Kutlu, Zeynep Kamil Women and Children’s Health Training and Research Hospital

Department of Reproductive Medicine and Infertlity

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Published

2018-08-10

How to Cite

1.
Yayla Abide C, Ozkaya E, Kayatas Eser S, Devranoğlu B, Bilgic BE, Kutlu T. Serum Albumin Level Adjusted Progesterone Level on the Trigger Day is Not a Significant Predictor of Clinical Pregnancy. Gynecol Obstet Reprod Med [Internet]. 2018Aug.10 [cited 2021Apr.15];24(2):87-91. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/771

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Section

Reproductive Medicine: Endocrinology and Infertility

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