Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Can be Useful Markers for Distinguishing Uterine Adenomyosis and Leiomyoma

Authors

  • Yusuf Madendag Health Sciences University Kayseri Training and Research Hospital http://orcid.org/0000-0002-7622-2991
  • Erdem Sahin Health Sciences University Kayseri Training and Research Hospital
  • Emine Aydin Health Sciences University Kayseri Training and Research Hospital
  • Ilknur Col Madendag Health Sciences University Kayseri Training and Research Hospital
  • Gokhan Acmaz Health Sciences University Kayseri Training and Research Hospital
  • Hatice Karaman Health Sciences University Kayseri Training and Research Hospital

DOI:

https://doi.org/10.21613/GORM.2017.716

Keywords:

Adenomyosis, Leiomyoma, Neutrophil to lymphocyte ratio, Platelet to lymphocyte ratio

Abstract

Objectıve: Both pelvic masses and preoperative diagnosis of them have still continued as an important investigation subject. It is important to discriminate the diagnoses of leiomyoma and adenomyosis before operation especially among infertile patients. Neoplasm can alter systemic or local immune response in their originating area. We aim to investigate using new inflammation markers, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, whether they are useful to discriminate between adenomyosis and leiomyoma.

Study Design: We reviewed a database of all patients that had complaint from abnormal uterine bleeding resistant to medical treatment or detected pelvic mass in perimenopausal period and underwent hysterectomy in our department between January 2011 and July 2016 for study groups. However, a total of 124 patients (44 adenomyosis and 80 leiomyoma) were evaluated because of exclusion criteria and matched with 72 women who were healthy and had normal uterus and ovaries as a control group.

Results: Neutrophil and platelet count, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio levels were significantly higher in adenomyosis group than in control group (p=0.039, p=0.046, p=0.001 and p=0.046 respectively). Neutrophil count and neutrophil to lymphocyte ratio levels were significantly higher in adenomyosis group than in leiomyoma group (p=0.039 and p=0.001, respectively).

Conclusıon: As a result, high neutrophil count and neutrophil to lymphocyte ratio levels may be useful marker to discriminate between adenomyosis and leiomyoma. Therefore, the examinations, which are more invasive and more expensive such as magnetic resonance imaging, may be less need by the agency of combined use of those inflammation markers and ultrasound in preoperative period.

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Author Biographies

Yusuf Madendag, Health Sciences University Kayseri Training and Research Hospital

obstetrics and gynecology

Erdem Sahin, Health Sciences University Kayseri Training and Research Hospital

obstetrics and gynecology

Emine Aydin, Health Sciences University Kayseri Training and Research Hospital

obstetrics and gynecology

Ilknur Col Madendag, Health Sciences University Kayseri Training and Research Hospital

obstetrics and gynecology

Gokhan Acmaz, Health Sciences University Kayseri Training and Research Hospital

obstetrics and gynecology

Hatice Karaman, Health Sciences University Kayseri Training and Research Hospital

Pathology

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Published

2018-12-25

How to Cite

1.
Madendag Y, Sahin E, Aydin E, Col Madendag I, Acmaz G, Karaman H. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Can be Useful Markers for Distinguishing Uterine Adenomyosis and Leiomyoma. Gynecol Obstet Reprod Med [Internet]. 2018Dec.25 [cited 2022Aug.14];24(3):147-50. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/716

Issue

Section

Gynecology and Gynecological Oncology

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