The Impact of Combined Oral Sildenafil and Inhaled Nitric Oxide for Treating Persistent Pulmonary Hypertension of the Newborn: A Single Center Experience

Authors

  • Hayriye Gozde Kanmaz Division of Neonatology, Zekai Tahir Burak Maternity Teaching
  • Mehmet Büyüktiryaki Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital
  • Şerife Suna Oğuz Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital
  • Evrim Dizdar Alyamac Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital
  • Fatma Nur Sarı Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital
  • Fuat Emre Canpolat Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital
  • Nurdan Uras Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital

DOI:

https://doi.org/10.21613/GORM.2016.656

Keywords:

Pulmonary hypertension, Newborn, Sildenafil, İnhaled nitric oxide

Abstract

Objective: We aimed to compare the effect of the combined therapy, sildenafil and inhaled nitric oxide with inhaled nitric oxide monotherapy for the treatment of Pulmonary Hypertension of the Newborn.

Study Design: Newborn infants (gestational age greater than 34 weeks) who were diagnosed with pulmonary hypertension between December 2008 and 2010 were retrospectively evaluated. Group I (n=14) received monotherapy with inhaled nitric oxide and Group II (n=9) received combined therapy with inhaled nitric oxide and oral sildenafil. Primary outcome was to compare the duration of inhaled nitric oxide therapy between groups.

Results: Demographic characteristics were similar between the groups. Combination therapy was associated with early weaning of inhaled nitric oxide (4.8±1.5 vs. 13.5±7.6 hours). The duration of inhaled nitric oxide therapy was slightly shorter in combined therapy group (75[24-125] vs. 109[24-210] hours), however, the difference was insignificant (p=0.2). The incidence of mortality and neonatal outcomes were similar between the groups (p>0.05).

Conclusion: Combined therapy did not result in shorter duration of inhaled nitric oxide therapy. Further well designed and larger studies that will elucidate the benefits of combination therapies and optimal therapy whereinhaled nitric oxide is not available are warranted.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2017-08-22

How to Cite

1.
Kanmaz HG, Büyüktiryaki M, Oğuz Şerife S, Dizdar Alyamac E, Sarı FN, Canpolat FE, Uras N. The Impact of Combined Oral Sildenafil and Inhaled Nitric Oxide for Treating Persistent Pulmonary Hypertension of the Newborn: A Single Center Experience. Gynecol Obstet Reprod Med [Internet]. 2017Aug.22 [cited 2021Apr.15];23(2):100-4. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/656

Issue

Section

Neonatology