Expression of Epidermal Growth Factor Receptor (Egfr) in Mole Hydatidiforms, Exaggarated Placental Sites and Normal Placentas and Ki 67 in Mole Hydatidiforms and Normal Placentas

Authors

  • Gökben Yıldırım Küpesiz The Department of Pathology, School of Medicine, Akdeniz University, Antalya
  • Hadice Elif Peştereli The Department of Pathology, School of Medicine, Akdeniz University, Antalya
  • Gülgün Erdoğan The Department of Pathology, School of Medicine, Akdeniz University, Antalya
  • Mehmet Şimşek The Department of Obstetrics and Gynecology School of Medicine, Akdeniz University, Antalya
  • Fatma Şeyda Karaveli The Department of Pathology, School of Medicine, Akdeniz University, Antalya

Keywords:

Mole hydatiform, Exaggerated placental site, Ki67 labeling index, EGFR (epidermal growth factor receptor)

Abstract

OBJECTIVE: The aim of this study is to find out differences between expression of EGFR (epidermal growth f actor receptor) and Ki 67 labeling index (LI) in complete, incomplete mole hydatidiforms, exaggareted placental sites and normal placentas.
STUDY DESIGN: Eighteen incomplete, 7 complete hy datidif orm moles, 19 exaggareted placental sites and 10 placentas (control group) were studied immunohistochemically for EGFR (epidermal growth f actor receptor)and Ki 67.
RESULTS: Ki 67 LI of villous cytotrophoblasts differed significantly between complete and incomplete hydatidiform moles (p < 0.01). Ki67 LIs of hydatidiform moles were significantly higher than control group (p < 0.001). EGFR (epidermal growth factor receptor)staining of villous cytotrophoblasts differed signif icantly between complete, incomplete hydatidiform moles and control group (p < 0.001). EGFR (epidermal growth f actor receptor) expression of syncytiotrophoblast differed signif icantly between complete, incomplete hydatidiform moles and control group (p < 0.001).
CONCLUSION: Expression of EGFR (epidermal growth f actor receptor)in syncytiotrophoblast and cy totrophoblasts is important in the pathogenesis of complete and incomplete hydatidiform moles. Ki67 LI can be a useful marker in differentiating complete and incomplete moles.

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Published

2006-08-17

How to Cite

1.
Yıldırım Küpesiz G, Peştereli HE, Erdoğan G, Şimşek M, Karaveli F Şeyda. Expression of Epidermal Growth Factor Receptor (Egfr) in Mole Hydatidiforms, Exaggarated Placental Sites and Normal Placentas and Ki 67 in Mole Hydatidiforms and Normal Placentas. Gynecol Obstet Reprod Med [Internet]. 2006Aug.17 [cited 2021Jun.23];12(2):82-4. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/573

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology