Recurrent Placental Abruption with Methylenetetrahydrofolate Reductase C667t Heterozygosity: A Case Report

Authors

  • Ilgın Türkçüoğlu Inonu University School of Medicine, Department of Obstetrics and Gynecology, Malatya
  • Yaprak Engin Üstün Inonu University School of Medicine, Department of Obstetrics and Gynecology, Malatya
  • Yusuf Üstün Inonu University School of Medicine, Department of Obstetrics and Gynecology, Malatya

Keywords:

Placental abruption, Thrombophilia, Methylenetetrahydrofolate reductase

Abstract

Placental abruption although uncommon, can result in high rate of maternal and fetal morbidity and mortality. Several studies suggest abnormal placental vasculature, thrombosis and reduced placental perfusion in pathophysiology. Genetic variations may predispose to these problems.
Case: A thirty year old 28 weeks pregnant women underwent cesarean section with the diagnosis of placental abruption, intrauterine dead fetus and previous cesarean section in our clinic. It was learned that she had a cesarean section due to placental abruption 1 year ago. In the postoperative period trombophilia markers, methylenetetrahydrofolate reductase , Factor V leiden and Prothrombin gene polymorphism, homocystein, folate and vitamin B12 levels and genetic karyotyping were evaluated. The only pathology was the metylenetetrahydrofolate reductase gene heterozygosity for the C to T substitution at nucleotide 677.
Risk of recurrence is high in patients with a history of placental abruption. Antenatal care and delivery after fetal lung maturation is advised since the perinatal mortality is high with placental abruption.

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Published

2007-12-16

How to Cite

1.
Türkçüoğlu I, Engin Üstün Y, Üstün Y. Recurrent Placental Abruption with Methylenetetrahydrofolate Reductase C667t Heterozygosity: A Case Report. Gynecol Obstet Reprod Med [Internet]. 2007Dec.16 [cited 2021Mar.7];13(3):176-8. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/545

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Section

Case Reports

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