Cleft Lip With or Without Cleft Palate: Prenatal Diagnosis, Chromosomal Abnormalities, Associated Anomalies and Postnatal Outcome in 18 Fetuses

Authors

  • Cem Batukan Erciyes University, School of Medicine Department of Obstetrics and Gynecology, Gevher Neshibe Hospital, Kayseri
  • Mahmut Özgün Erciyes University, School of Medicine Department of Obstetrics and Gynecology, Gevher Neshibe Hospital, Kayseri
  • Mustafa Başbuğ Erciyes University, School of Medicine Department of Obstetrics and Gynecology, Gevher Neshibe Hospital, Kayseri
  • Hülya Akgün Erciyes University, School of Medicine Department of Pathology, Gevher Neshibe Hospital, Kayseri

Keywords:

Cleft lip/palate, Associated anomalies, Fetus, Ultrasound, Prenatal diagnosis

Abstract

OBJECTIVE: The aim of this study was to present our experience with prenatal diagnosis of cleft lip and/or palate (CL/P) and to determine the relationship between facial clefts, associated malformations and chromosomal anomalies.
STUDY DESIGN: Data of 18 fetuses with prenatally diagnosed CL/P were retrospectively analyzed. Postnatal outcome and incidence of additional malformations and chromosomal abnormalities were determined.
RESULTS: Postnatal findings confirmed that the type of cleft was median CL+P (n=3), bilateral CL+P (n=5), unilateral CL+P (n=5), unilateral CL (n=5). Eight cases were diagnosed at or before 24 weeks of gestation. Eleven fetuses (%61) had additional structural anomalies. Abnormal fetal karyotype was present in 5 fetuses (two cases with trisomy 13 and three cases with trisomy 18). All fetuses with isolated
CL/P survived after surgery. Termination of pregnancy was requested in nine fetuses with additional anomalies and/or chromosomal anomalies, whereas one each of the fetuses died in utero or early neonatal period.
CONCLUSION: In pregnancies complicated with CL/P, patients should be informed about the risk of associated anomalies, chromosomal abnormalities and syndromic conditions.

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Published

2007-04-15

How to Cite

1.
Batukan C, Özgün M, Başbuğ M, Akgün H. Cleft Lip With or Without Cleft Palate: Prenatal Diagnosis, Chromosomal Abnormalities, Associated Anomalies and Postnatal Outcome in 18 Fetuses. Gynecol Obstet Reprod Med [Internet]. 2007Apr.15 [cited 2021Apr.15];13(1):4-8. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/502

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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