Determining the Risk of Premenopausal Endometrial Carcinoma by Analysing Expression of c-eErb-B2 in Patients with Polycystic Ovary Syndrome

Authors

  • Feyza Arman Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara
  • Tayfun Güngör Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara
  • Levent Şirvan Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Pathology, Ankara
  • Özlem Altınkaya Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara
  • Banu Mat Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara
  • Yeksin Helvacıoğlu Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara
  • Ümit Bilge Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara
  • Leyla Mollamahmutoğlu Dr. Zekai Tahir Burak Women’s Health Care Education and Research Hospital Department of Gynecologic Oncology, Ankara

Keywords:

c-erb-B2, Endometrial carcinoma, PCOS

Abstract

OBJECTIVE: The present study aims to determine the risk of premenopausal endometrial carcinoma by analyzing c-erb-B2 overexpression in patients with polycystic ovary syndrome (PCOS).
STUDY DESIGN: A total of 20 women with PCOS, 20 premenopausal women under the age of 50 with endometrial carcinoma and 20 healthy women were eligible for the study.
RESULTS: 18 (90%) of the endometrial cancers were endometrioid adenocarcinoma. C-erb-B2 overexpression, was found in 4 (20%) of endometrial cancer cases. Women with endometrial cancer were found to have significantly higher c-erb-B2 overexpression compared to women with PCOS and with normal endometrial biopsy (p=0.037). Polycystic ovaries (PCO), as a marker of PCOS, were investigated
histologically from 10 of the 20 (50%) women with endometrial cancer. Comparing women with endometrial cancer on their own in terms of c-erb-B2 expression, no significant difference was found in PCO existence (p>0.05), and in terms of PCO existence, there was no significant difference in c-erb-B2 expression and age however, PCO (+) women were slightly younger than PCO (-) ones. All of the PCO
(+) women had obesity, as compared to PCO (-) ones (p=0.005).
CONCLUSION: C-erb-B2 overexpression appears to play a role in endometrial carcinomas. In women with endometrial cancer, although no significant difference is found, lower mean age of PCO (+) patients preoccupies the possibility of developing cancer at early ages in PCOS. c-erb-B2 overexpression is not found in the endometrial tissues from women with PCOS and is therefore not a determining factor for endometrial cancer among these women.

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Published

2010-04-10

How to Cite

1.
Arman F, Güngör T, Şirvan L, Altınkaya Özlem, Mat B, Helvacıoğlu Y, Bilge Ümit, Mollamahmutoğlu L. Determining the Risk of Premenopausal Endometrial Carcinoma by Analysing Expression of c-eErb-B2 in Patients with Polycystic Ovary Syndrome. Gynecol Obstet Reprod Med [Internet]. 2010Apr.10 [cited 2021Jun.23];16(1):45-50. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/335

Issue

Section

Gynecology and Gynecological Oncology

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