Chromosome Abnormalities in Turkish Men with Primary Infertility

Authors

  • Tayfun Güngör Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, Ankara
  • Mine Kanat Pektaş Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, Ankara
  • Müfit Günel Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Andrology, Ankara
  • Leyla Mollamahmutoğlu Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, Ankara

Keywords:

Azoospermia, Chromosomal abnormality, Klinefelter syndrome, Male infertility, Spermiogram

Abstract

OBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility.
STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control group.
RESULTS: Azoospermia is defined to be the most frequent spermiogram abnormality within infertile men, followed by oligoasthenoteratozoospermia. Chromosomal abnormalities were demonstrated to occur significantly more in azoospermic subjects (28.3%) compared to other infertile subjects (11.5%) and fertile men (0.8%). Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%. Azoospermia Factor (AZF) microdeletions occur statistically similar among azoospermic men (4.2%) and other infertile men (2.3%), with a total frequency of 3.2%.
CONCLUSION: The high rate of chromosomal anomalies among infertile Turkish men strongly suggests the need for routine cytogenetic analysis prior to the application of assisted reproduction techniques.

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Published

2010-04-10

How to Cite

1.
Güngör T, Kanat Pektaş M, Günel M, Mollamahmutoğlu L. Chromosome Abnormalities in Turkish Men with Primary Infertility. Gynecol Obstet Reprod Med [Internet]. 2010Apr.10 [cited 2021Jun.23];16(1):32-6. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/332

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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