The Influence of Natural and Surgical Menopause on Cardiovascular Risk Markers Folate and Vitamin B12 Levels

Authors

  • Hakan Kıran Kahramanmaras Sutcuimam University School of Medicine Department of Obstetrics and Gynecology, Kahramanmaraş
  • Deniz Cemgil Arıkan Kahramanmaras Sutcuimam University School of Medicine Department of Obstetrics and Gynecology, Kahramanmaraş
  • Gürkan Kıran Kahramanmaras Sutcuimam University School of Medicine Department of Obstetrics and Gynecology, Kahramanmaraş
  • Ayhan Coşkun Kahramanmaras Sutcuimam University School of Medicine Department of Obstetrics and Gynecology, Kahramanmaraş
  • Semih Yancar Kahramanmaras Sutcuimam University School of Medicine Department of Obstetrics and Gynecology, Kahramanmaraş
  • Abdullah Tok Agri State Hospital, Department of Obstetrics and Gynecology, Ağrı
  • Hasan Çetin Ekerbiçer Kahramanmaras Sutcuimam University School of Medicine Department of Public Health, Kahramanmaraş

Keywords:

Cardiovascular risk, Folate, Vitamin B12, Menopause

Abstract

OBJECTIVE: To investigate the influence of both natural and surgical menopause on serum concentrations of lipids, lipoprotein-a, C-reactive protein, homocysteine, folate and vitamin B12 levels.
STUDY DESIGN: The study included 126 healthy women: 20 perimenopausal, 62 natural menopausal, and 44 surgical menopausal women. The serum levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, lipoprotein-a, C-reactive protein, homocysteine, folate and vitamin B12 levels were measured, and comparisons were made between the groups.
RESULTS: The plasma levels of total cholesterol, triglyceride, lipoprotein-a, homocysteine and folate were non-significantly higher in natural menopause group compared to perimenopause group. Also plasma total cholesterol, lipoprotein-a, homocysteine, vitamin B12 levels were higher and high-density lipoprotein cholesterol level was lower in surgical menopause group compared to perimenopause group, the difference was not significant. The plasma level of low-density lipoprotein cholesterol was significantly higher in natural menopausal women than perimenopausal women (p<0.05). Surgical menopausal women had higher but non-significant low-density lipoprotein cholesterol levels than perimenopausal
women. There was a negative correlation between age and high-density lipoprotein cholesterol in natural menopause group, and there was a positive correlation between age and homocysteine in natural and surgical menopausal groups (p<0.05).
CONCLUSION: We did not find any significant difference in studied cardiovascular risk markers, folate and vitamin B12 levels in perimenopausal and postmenopausal women except low-density lipoprotein cholesterol levels.

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Published

2011-08-09

How to Cite

1.
Kıran H, Cemgil Arıkan D, Kıran G, Coşkun A, Yancar S, Tok A, Ekerbiçer H Çetin. The Influence of Natural and Surgical Menopause on Cardiovascular Risk Markers Folate and Vitamin B12 Levels. Gynecol Obstet Reprod Med [Internet]. 2011Aug.9 [cited 2021Mar.3];17(2):90-7. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/299

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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