The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy

Authors

  • Şafak Özdemirci Simav Government Hospital, Kütahya
  • Funda Akpınar Etlik Zübeyde Hanım Gynecology Education and Research Hospital, Ankara
  • Melek Bilge Dr Faruk Sükan Women Health and Child Hospital Konya
  • Funda Özdemirci Başkent University, Ankara Başkent Hospital Family Medicine Department, Ankara
  • Saynur Yılmaz Etlik Zübeyde Hanım Gynecology Education and Research Hospital, Ankara
  • Deniz Esinler Etlik Zübeyde Hanım Gynecology Education and Research Hospital, Ankara
  • İnci Kahyaoğlu Etlik Zübeyde Hanım Gynecology Education and Research Hospital, Ankara

Keywords:

Nausea and vomiting of pregnancy (NVP), Ondansetron, Chlorpromazine, First trimester pregnancy

Abstract

OBJECTIVE: To evaluate the pregnancy outcome of women with nausea and vomiting of pregnancy (NVP) who were treated with either ondansetron or chlorpromazine.
STUDY DESIGN: This retrospective study included 185 women who were hospitalized in the first trimester for treatment of NVP and treated with either ondansetron or chlorpromazine between January 2006 and March 2011 at Simav Government Hospital. We evaluated the pregnancy outcome including birth weight, pregnancy induced hypertension, preterm birth and major congenital malformations.
RESULTS: In the ondansetron group 4 (4%) low birth weight newborn, 9 (9%) preterm birth and 1 (1%) congenital anomaly, while in chlorpromazine group 1 (1.2%) low birth weight newborn, 9 (10.6%) preterm birth and 4 (4.7%) congenital anomalies were observed.
CONCLUSION: The malformation risk for both drugs found to be similar to baseline. Although the sample size was small, both drugs found to be safe to use in first trimester for NVP.

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Published

2014-08-29

How to Cite

1.
Özdemirci Şafak, Akpınar F, Bilge M, Özdemirci F, Yılmaz S, Esinler D, Kahyaoğlu İnci. The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy. Gynecol Obstet Reprod Med [Internet]. 2014Aug.29 [cited 2021Sep.26];20(2):81-4. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/140

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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