The Effect of Different Doses of Intraamniotic Digoxin on the Timing of Fetal Demise in Second Trimester Medical Abortions

Authors

DOI:

https://doi.org/10.21613/GORM.2022.1304

Keywords:

Digoxin, Feticide, , Medical abortion

Abstract

OBJECTIVES: The World Health Organization recommends feticide for termination of pregnancy after 20 weeks of gestation, and the Royal College of Obstetricians & Gynecologists after 21 weeks and 6 days. Digoxin is a commonly used feticidal agent. This retrospective study aimed to show the effect of different doses of digoxin on the timing of fetal demise when used for feticide.

STUDY DESIGN: Our retrospective cohort study included 57 patients who underwent feticide by routine intra-amniotic digoxin 0.75 mg or 1 mg between 2016 and 2018 at the Ataturk University Medical Faculty Research Hospital. The patients were administered undiluted digoxin 0.75 mg (3 ccs) or 1 mg (4 ccs) with a 20-gauge spinal needle inserted through the amniotic membrane. After digoxin administration, the fetal heartbeat was monitored every hour by ultrasound, and recorded.

RESULTS: In this retrospective study, we reviewed the data of 61 patients who underwent feticide by intra-amniotic digoxin 0.75 mg and 1 mg. Digoxin 3 ccs (n=23) and digoxin 4 ccs (n=34). The two groups were not significantly different in terms of age, gestational week, and termination indications. We reviewed the medical records of all subjects and noted any side effects.

CONCLUSIONS: In our study, we investigated the effect of different doses of intra-amniotic digoxin on the fetal demise in accordance with the literature. Despite our small sample size, we conclude that a higher dose of digoxin will reduce the time to asystole and minimize the mental burden of the procedure on the patient.

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Published

2022-08-02

How to Cite

1.
Aynaoglu Yildiz G, Al RA. The Effect of Different Doses of Intraamniotic Digoxin on the Timing of Fetal Demise in Second Trimester Medical Abortions. Gynecol Obstet Reprod Med [Internet]. 2022Aug.2 [cited 2022Aug.14];28(2):118-21. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/1304

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology