Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery

Authors

DOI:

https://doi.org/10.21613/GORM.2021.1193

Keywords:

Antibiotic prophylaxis, Cefazolin, Surgical site infection, Topical rifamycin

Abstract

OBJECTIVE: Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations. Rifamycin is a broad-spectrum semisynthetic antibiotic that is bactericidal against gram (+) and gram (˗) microorganisms. To the best of our knowledge, there are no studies on the use of rifamycin in antibiotic prophylaxis. In this study, we aimed to analyze whether there is a difference between the use of only cefazolin and only rifamycin in terms of surgical site infections.

STUDY DESIGN: One hundred patients were included in this case-control study during the last quarter period of 2017. These patients (n=100) were divided into two groups according to their antibiotic use; 50 patients who received only 1 g cefazolin constituted Group 1, 50 patients who received only 250 mg topical rifamycin over the incision line based on surgeon’s preference constituted Group 2.

RESULTS: The use of prophylactic topical rifamycin reduced the incidence of wound infection. compared with cefazolin. Surgical site infection was detected in 5 (10%) of the patients who received cefazolin, whereas surgical site infection was not observed in patients who received rifamycin (p=0.022).

CONCLUSIONS: The use of topical rifamycin is effective but does not imply that systemic antibiotics should replace prophylaxis. The use of rifamycin would aid in systemic antibiotic prophylaxis.

Downloads

Download data is not yet available.

Downloads

Published

2022-03-30

How to Cite

1.
Ata N, Kulhan M, Kulhan NG, Turkler C, Bilgi A, Celik C. Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery. Gynecol Obstet Reprod Med [Internet]. 2022Mar.30 [cited 2024Mar.29];28(1):76-81. Available from: https://www.gorm.com.tr/index.php/GORM/article/view/1193

Issue

Section

Gynecology and Gynecological Oncology